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Betalin Therapeutics Ltd.
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  5. Betalin - Micro-Organ Matrix (MOM) ...

Betalin - Micro-Organ Matrix (MOM) Technology

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Due to the importance in the ECM in islet function, Betalin have developed a MOM scaffold that used a decelluarized ECM (a process to isolate the ECM from its cells). This aims to mimic the islets natural microenvironment, providing the islet cells with all the required nutrients and gases for survival. The MOM allows a complex network of vascularization, so no islet cell will be starved, which improves the longevity of islet cells. 

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  • Decellularized lung-derived scaffolds demonstrate eutrophic effect on β-cell function, which may be explained by the extensive capillary network present in the lung that providing the necessary basement membrane components essentials for beta cell functioning.
  • Our in vitro data indicates that MOM supports islets for regulated insulin secretion in vitro for at least 28 days, and with higher levels of insulin compared to naked islets.
  • EMPs efficiently support islet function as demonstrated by their ability to reverse hyperglycaemia for up to 90 days in a mouse model