Model 75-266 - Anti-Dardarin/LRRK2, N3 (Non-Mouse-Reactive) Antibody (N231B/34)
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Clonality: Monoclonal
Clonality: Monoclonal
Applications: IHC, ICC, WB
Host Species: Mouse
Gene Name: LRRK2 PARK8
Molecular Weight: >200 kDa
Product Details
Target: Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin)
Target Description: LRRK2 (also known as PARK8) encodes a protein with 5 putative functional domains: an N-terminal leucine-rich repeat (LRR) domain, a Roc (Ras of complex protein) domain that shares sequence homology to the Ras-related GTPase superfamily, a COR (C-terminal of Roc) domain, a mitogen-activated protein kinase kinase kinase (MAPKKK) domain, and a C-terminal WD40 repeat domain. Mutation in this gene is one of the most common causes of inherited Parkinson disease (Gandhi et al., 2008). LRRK2 was originally identified as a putative disease-causing transcript (DKFZp434H2111) within a 2.6-Mb region encompassing a locus for Parkinson disease-8 (PARK8). Northern blot analysis detected a 9-kb mRNA transcript in all tissues tested, including brain. The authors named the protein product dardarin, derived from the Basque word dardara, meaning tremor. LRRK2/dardarin is also known to positively regulate autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway and together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. LRRK2/PARK8 is also known to regulate neuronal process morphology in the intact central nervous system (CNS) and play a role in synaptic vesicle trafficking.
Format: Purified
Concentration: 1 mg/mL
Clonality: Monoclonal
Clone: N231B/34
Antibody Isotype: IgG2a
Applications: IHC, ICC, WB
Host Species: Mouse
Gene Name: LRRK2 PARK8
Molecular Weight: >200 kDa
Antigen: Fusion protein amino acids 841-960 of human LRRK2 (also known as Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin and PARK8, accession numberQ5S007); Mouse: 81% identity (98/120 amino acids identical); Rat: 80% identity (97/120 amino acids identical) 30% identity with LRRK1
Species Reactivity: Human, Mouse, Rat
Antibody Registry ID: AB_11000724
Storage: Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Physical State: Liquid
Conjugate: Unconjugated
Usage Statement: These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Country of Origin: United States
Expiration: 24 months from opening
Synonyms: Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin)
UniProt Details: UniProt (Human): Q5S007; UniProt (Immunogen Species): Q5S007
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