Model ALZ-201 - Monoclonal Antibody for the Toxic Aß Oligomers
ALZ-201 is a monoclonal antibody that is specific for the toxic Aβ oligomers. ALZ 201 is currently in early preclinical development.
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Preclinical Development
ALZ-201 was developed using ALZ-101. It is a murine monoclonal antibody of IgG type that is extremely specific for the Aβ42CC oligomers. It completely lacks affinity for monomers, fibrils and all forms of Aβ40. It does not bind the plaques of humans.
Immuodepletion of brain extracts demonstrates that the native Aβ targeted by this antibody is not detectable using Western blots. Despite this, it has a profound effect on the toxicity of the brain extracts, indicating that the amounts of toxic Aβ42 in patient brains are very low.
ALZ-201 is thus a novel antibody with a specificity that differs from known antibodies, and further substantiates that there are oligomer-specific epitopes in full-length Aβ42 that can be targeted with very high specificity without also targeting monomers and fibrils.
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