Model GI-301 - Novel Immunoglobulin E (IgE) Trap Fusion Protein for Allergic Diseases
A novel long-acting lgE Trap-Fc fusion protein for allergic diseases; Broad therapeutic efficacy for IgE-mediated hypersensitivity reaction. Sufficient IgE control capacity for patients with high IgE levels. Low risk of anaphylactic shock and immunogenicity. High safety in GLP toxicity study.
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Details:
Hypersensitivity reaction
- When the immune system is exposed to foreign antigens, IgE and autoantibody (anti-FcεR1α) are expressed.
- These antibodies can bind to FcεR1α of mast cells, activating the cells.
- Activated mast cells release histamine, increasing blood histamine levels causing hypersensitivity reaction.
Dual action of GI-301
- GI-301 has two functional groups that can each bind to IgE and autoantibody (anti-FcεR1α) with high affinity, inhibiting the activation of mast cells.
- Mast cell deactivation decreases the histamine concentration in the blood, alleviating hypersensitivity reaction.
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