Krillase - Extract of Antarctic Krill
Krillase- Extract of Antarctic Krill comprised of a complex of several proteases that are highly active over a wide temperature range. The activity of Krillase at low temperatures offers distinct advantages over other enzymes typically used in the isolation of cells from tissues and organs. Krillase has been shown to be active in the removal or biofilm from soft and hard tissues, and has applications in wound debridement/skin grafting. Krillase-based products are currently under development for the veterinary market for plaque reduction in dogs and cats. Krillase is not yet approved for use in the US.
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Krillase activity is unique – it is the only enzymatic product based on a co-operative multi-enzyme system involving both endo- and exopeptidases.
The proteolytic enzymes of Krillase are composed of eight natural enzymes acting in a synergetic manner, including:
- Three serine proteinases with trypsin-like activity (one endo/exopeptidases, two endopeptidase),
- One serine proteinase with chymotrypsin-like activity, and
- Four exopeptidases (two carboxypeptidases A and two carboxypeptidases B).
Krill enzymes are also unique in that they are mutually protected against the degrading effect of each other and they act in a two-step fashion when breaking down proteinaceous substrates.
- First, endopeptidases attack peptide bonds of the infrastructural parts of the polypeptide chains.
- The resulting peptide fragments are subsequently cleaved by exopeptidases into small peptides and free amino acids.
Marizyme currently has four product candidates derived from Krillase.
- MB101 to debride and heal human wounds
- MB101 was tested in multiple clinical stage studies conducted by ACB Holding AB prior to its acquisition by Marizyme.
- In these studies, which were designed as Phase II efficacy studies and conducted in several European countries, patients were treated for wound debridement and healing.
- No clinical trials of MB101 have been conducted in the United States.
- MB101 was tested in multiple clinical stage studies conducted by ACB Holding AB prior to its acquisition by Marizyme.
- MB102 for acute cerebral ischemic stroke
- MB104 to treat deep vein thrombosis
- MB105 to dissolve plaque and biofilms on teeth
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