Model SG-5-00455 - Plasminogen Activator Inhibitor
SG-5-00455 binds to plasminogen activator inhibitor (PAI)-1/2, blocking the inhibitory effect of PAI-1/2 and ultimately reducing fibrosis and improving mucosal healing. We set out to address a high unmet need in patients with gastrointestinal disorders by finding a protein(s) expressed by healthy microbiome that induce mucosal repair and developed that protein(s) into a naturally derived, safe and potent therapy to improve outcomes for patients.
Details
Indication:
Inflammatory bowel diseases (IBD)
Administration:
oral, via engineered L. lactis
Goal:
achieve mucosal healing
Discovered:
healthy guts
peptidePeptide: SG-2-0776
targetTarget: PAI-1 / PAI-2
IP filed
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