MultiScan - Model LFER150 PET/CT - Large FOV Extreme Resolution Research Imager
The MultiScan™ Large Field of view Extreme Resolution PET/CT system is offering molecular imaging with high spatial resolution and high quantitative accuracy in a gantry that supports all possible non-human primate (NHP) studies. Fine crystal needles and advanced detector modelling of the Tera-Tomo™ 3D PET reconstruction enable to resolve 1 mm structures. Our highly refined detector technology and dead time estimation maintain 97% quantitative accuracy up to 150 MBq (4mCi) activity level. Both PET and CT can image the very same region of space, making any patient movement unnecessary in a single field of view study. The freely tilting detector head enables even awake animal imaging with visual stimuli.
Features & Benefits
Precise quantification of tiny objects, like the substantia nigra in the brain or tuberculosis granulomas in the lungs, require high spatial resolution.
- MultiScan™ LFER 150 PET/CT can achieve better than 1 mm spatial resolution
- This translates to more than 75% recovery for the 2 mm rod in the NEMA image quality test
- Using precise detector modelling and attenuation and scatter correction in the Tera-Tomo™ 3D PET reconstruction the system achieves better than 5% homogeneity measured with a 15 cm diameter water filled phantom.
Applications involving short half-life isotopes, like 11C and 15O or long scan times, like cell tracking require good quantitative accuracy over a wide range of radioactivity levels.
- Due to its powerful read-out electronics and efficient dead-time compensation the MultiScan™ LFER150 PET/CT features a peak noise equivalent count rate (NECR) of 398 kcps @ 149 MBq for rat-like and 64.7 kcps @ 128 MBq for monkey-like phantoms (NEMA)
- Moreover, it enables better than 3% accuracy for up to 150 MBq in the field of view, independent from the size of the object
- Low activity imaging is ensured by high sensitivity of over 5%.
The high, isotropic spatial resolution of the CT system is very suitable for characterizing and tracking tuberculosis granulomas.
- The cone-beam CT delivers better than 200 µm isotropic spatial resolution with 50 µm voxel size
- Full tomographic scans of less than 40 seconds allowing breath-hold CT imaging
- High resolution lung scans in smaller animals are supported by respiratory gating
- Noise performance and soft tissue contrast are improved by iterative CT reconstruction.
There are 7 MultiScan™ LFER150 PET/CT running worldwide in laboratories operating under biosafety level 3 (BSL-3) conditions.
These systems perform up to 1000 scans per year and regularly endure sterilization.
Research is focusing on wide range of infectious diseases including vaccine development for COVID-19.
The compact and versatile gantry has two animal support modules:
- MobilCell animal bed:
- Up to 60 cm imaging length
- Fits up to 16 kg (35 lb) rhesus monkeys
- Compatible with MultiCell imaging chambers for rodent, including heating and physiological monitoring
- Primate chair:
- Awake non-human primate studies
- Freely tilted gantry covers the brain while ensures free visibility for application of visual stimuli, like no system before.
Specifications
PET
Gantry opening: 26 cm
Transaxial FOV: 20 cm
Axial FOV: 15 cm
Animal models: up to 16 kg Rhesus or 4 mice simultaneously
Multiple animal imaging: up to 4 x 60 g mice 2 x 500 g rats
Detector crystal: LYSO (1.51 x 1.51 x 10 mm)
Spatial resolution with Tera-Tomo (3D OSEM): 1 mm
Sensitivity: 5%
Noise Equivalent Count Rate for rat (NEMA): 398 kcps @ 148 MBq
Noise Equivalent Count Rate for monkey (NEMA): 64.7 kcps @ 128 MBq
CT
X-ray power: up to 80 W
Gantry opening: 26 cm
Transaxial FOV: 20 cm
Axial FOV: 15 cm
Extended axial FOV: 60 cm
Animal models: up to 16 kg Rhesus or 4 mice simultaneously
Multiple animal imaging: up to 4 x 60 g mice 2 x 500 g rats
Acquisition time (full tomographic): < 40 sec
Image reconstruction: modified Feldkamp-type for real-time reconstruction, iterative for low-dose and low-noise applications
Spatial resolution: < 200 µm @ 10% MTF with 50 µm voxel size
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