Elicio -Model ELI-008 -Multivalent Lymph Node–Targeted AMP Peptide Vaccine

ELI-008 is a multivalent lymph node–targeted AMP peptide vaccine developed to target p53 hotspot mutations. p53 is a tumor-suppressing protein that controls the cell cycle, DNA replication, and uncontrolled cell division during tumor growth.⁴ Mutations in the p53 protein lead to uncontrolled tumor progression and growth.⁴ Similar to Kristen rat sarcoma (KRAS), p53 mutations are present in a broad spectrum of cancer types, accounting for approximately 30% of solid tumors. We designed ELI-008 to target p53 hotspot mutations in solid tumor cancers, including melanoma, CRC, and non-small cell lung cancer (NSCLC).