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Model 1600 - Neuroprobe Amplifier

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The Neuroprobe Amplifier Model 1600: Designed to surpass the exacting requirements of intracellular neurological studies and provide the research scientist with versatility, accuracy and ease of operation. The instrument consists of a high input impedance amplifier combined with current injection and bridge balance circuitry, allowing simultaneous stimulation and recording through the same electrode. The internal Dual-Function Transient Control and the DC balance Control assure extremely precise recordings during current injection without requiring an external bridge or a differential input oscilloscope. High-resolution ten-turn potentiometers are used for the DC Offset, DC balance, Current Injection, and Capacitance Compensation controls. Measure electrode resistance and adjust capacitance compensation using the internal 100 Hz test pulse. An easy to read Digital Panel Meter produces a highly accurate display of membrane potential, injected current or electrode resistance

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The Neuroprobe Amplifier`s advanced current injection system, adjustable to 0.1 nA resolution, allows external switching of both internal and external current sources. The total current from all sources can be displayed on the Digital Panel Meter prior to injection. This capability allows the user to inject the exact amount of current desired. Depending upon the requirements of the experiment, the user can also select either momentary or continuous injection.

This Iontophoresis Adapter allows the researcher to apply greater voltages to the micropipette for iontophoretic injection of drugs or dyes, or any other application where currents greater than those provided by the Neuroprobe Amplifier are required.

Current Input
  • Impedance: 1011?
  • Capacitance: Adjustable to zero
  • Working Range: ± 2.5 V
  • Maximum Range: ± 10 V
  • Iontophoresis Adapter Input: ± 200 V
Current Injection: External Source
  • Input Impedance: 20 k?
  • Frequency Range: DC to 250 kHz
  • Low Range Maximum Current: 10 nA/V
  • Low Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 108 V?)/(electrode resistance)
  • High Range Maximum Current: 100 nA/V
  • High Range Maximum Voltage: lesser of ± 10V and (± 2.5 x 107 V?)/(electrode resistance)
Current Injection: External Source
  • Low Range Maximum Current: lesser of ± 100 nA and 2.5 V/(electrode resistance)
  • Low Range Maximum Voltage: lesser of ± 1000 nA and 2.5 V/(electrode resistance)
Current Gate
  • ON Signal: + 2.5 V (Step with rise time 10 µsec)
  • OFF Signal: +0.6 V
  • Maximum Input: ± 15 V
  • Input Impedance 20 k?
Electrode Test: External Signal Source
  • Input Impedance: 10 k?
  • Input Voltage Range: ± 10 V
  • Low Range Scale Factor (x1 Output): 1 mV/M?/(input voltage)
  • High Range Scale Factor (x1 Output): 10 mV/M?/(input voltage)
Electrode Test: Internal Signal Source
  • Signal: 100 Hz Square Wave
  • Low Range Scale Factor (x1 Output): 1 nA p-p produces 1 mV/M?
  • High Range Scale Factor (x1 Output): 10 nA p-p produces 1 mV/M?
Signal Processing: Input Bias Current
  • Optimal: Adjustable to Zero
  • Maximum without adjustment, Low Range: 3x10-12 Amp
  • Maximum without adjustment, High Range: 3x10-11Amp
  • Drift vs Temperature, Low Range: 1x10-13 Amp/°C
  • Drift vs Temperature, High Range: 1x10-12 Amp/°C
  • Drift vs Time, Low Range: 3x10-13 Amp/12 hours
  • Drift vs Time, High Range: 3x10-12 Amp/12 hours
Signal Processing: Frequency Response
  • Frequency Range: DC to 325 kHz
Signal Processing: Rise Time
  • Square Wave (500 mV) 50 ? Source: 0.8 µsec (10% to 90%)
  • Square Wave (500 mV) 20 M? Source: 7.0µsec (10% to 90%)
Signal Processing: Zero Stability
  • Stability vs Temperature: 200 µV/°C
  • Stability vs Time:1 mV/12 hours
Signal Processing: Low Pass Filter
  • Cut-off Frequencies (-3 dB): 1, 2, 5, 10, 20, 50, 100 kHz
  • Slope: -12 dB/octave
Signal Processing: Notch Filter
  • Center Frequency: 50 Hz or 60 Hz (factory preset)
  • Q: 10
  • Rejection: -50 dB
Signal Processing: Capacitance Compensation
  • Range: -4 pF to +30 pF
Signal Processing: Internal Calibration Voltage
  • 10mV: ± 1%
  • 1000mV: ± 1%
Signal Processing: Noise
  • 0 ? Source: 13 µV RMS (10Hz to 50kHz)
  • 1 M? Source: 79 µV RMS (10Hz to 50kHz)
  • 20 M? Source: 310 µV RMS (10Hz to 50kHz)
Signal Processing: DC Balance
  • Low Range: up to 500 M?
  • High Range: up to 50 M?
Output x1
  • Voltage Gain: 1.00 ± 0.1%
  • Maximum Voltage: ± 10V
  • Impedance: 220 ?
  • DC Offset Range: 0.0 V to ± 1.0 V
Output x10
  • Voltage Gain: 10.00 ± 1.0%
  • Maximum Voltage: ± 10 V
  • Impedance: 220 ?
  • DC Offset Range: 0.0 V to ± 10.0 V
Output: Current Monitor
  • Low Range Scale Factor: 10 mV/nA
  • High Range Scale Facto: 1 mV/nA
  • Maximum Output: ± 1.0 V
  • Output Impedance: 1 k?