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SMART nano-particleNext-Generation Nanotechnology

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Creating formulations that are truly effective means finding an answer to the question of solubility – and that answer can be found in LEON’s unique approach to nano. For both New Chemical Entities (NCEs) and generics, our intelligence in nanotechnology provides a clear solution to poor solubility and paves the way for downstream processing. With this we address unmet patient needs and unlock new value from APIs for pharmaceutical partners. Our solution is based on patented technologies to deliver a classic bottom-up approach to the synthesis of SMART nanoparticles or microparticles. This results in the continuous precipitation of particle sizes between 10 nm and to 70 µm with consistent reproducibility and at a cost comparative to standard technologies for small and large scales.

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Our development pathway and equipment allows easy scale-up to test prototype nano formulations as well as to support clinical and commercial availability. New formulations can be developed faster and the process can be validated easily. Thus, positive impacts for patients can be achieved faster.

  • Standardized, continuous processing
  • Easily scalable
  • Proprietary Technology
  • Particle tolerances between 10 nm – 1000 nm and 1-70 µm
  • Suitable for range of drug delivery dosage forms

Stable crystalline or polymeric particles
Measurable tailored size: 10 nm – 70 µm
Achievable easy scale-up: bench to commercial
Relevant for all application forms
Timebound: fast continuous precipitation < 0.1 ms easily integrated into downstream processes