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Model PyOxim - Novel and Highly Efficient Coupling Reagent
PyOxim® is a novel and highly efficient coupling reagent that mediates coupling reactions with efficiencies superior to HATU and PyBOP® and comparable to COMU®. CAS: 153433-21-7. Synonym:1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate; O-[(1-cyano-2-ethoxy-2-oxoethylidene)amino]-oxytri(pyrrolidin-1-yl) phosphonium hexafluorophosphate
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Purity
≥99.0%
Molecular Formula
C17H29F6N5O3P2
Molecular Weight
527.38 [gr/mol]
Appearance
White crystalline powder
Storage Conditions
Store in a cool and dry place (2-8oC)
- It has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days.
- PyOxim® shows higher stability in acetone and DMF than all benzotriazole counterparts, consequently standing out as promising choice for cyclization.
- Furthermore, PyOxim® is safer to handle and less allergenic than HOBt-based coupling reagents, and it is not explosive under normal operating conditions.