Logo Medical XPRT
Companies
Products
Services
Software
Training
Applications
Sign in
List your business
GI Innovation
About
  2. Companies
  3. GI Innovation
  4. Products
  5. Model GI-301 - Novel Immunoglobulin E ...

Model GI-301 - Novel Immunoglobulin E (IgE) Trap Fusion Protein for Allergic Diseases

SHARE

A novel long-acting lgE Trap-Fc fusion protein for allergic diseases; Broad therapeutic efficacy for IgE-mediated hypersensitivity reaction. Sufficient IgE control capacity for patients with high IgE levels. Low risk of anaphylactic shock and immunogenicity. High safety in GLP toxicity study.

Most popular related searches
immunoglobulin e
immune system
allergy
antigen anti

Hypersensitivity reaction

  • When the immune system is exposed to foreign antigens, IgE and autoantibody (anti-FcεR1α) are expressed.
  • These antibodies can bind to FcεR1α of mast cells, activating the cells.
  • Activated mast cells release histamine, increasing blood histamine levels causing hypersensitivity reaction.

Dual action of GI-301

  • GI-301 has two functional groups that can each bind to IgE and autoantibody (anti-FcεR1α) with high affinity, inhibiting the activation of mast cells.
  • Mast cell deactivation decreases the histamine concentration in the blood, alleviating hypersensitivity reaction.