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Novel Skin Delivery Technology
Delivering pharmaceuticals to the skin to treat disease is challenging. The skin’s role is to protect the body from a range of chemical and environmental assaults, so bypassing this active system requires an innovative approach. Botanix has exclusively licensed a novel transdermal drug delivery solution known as Permetrex™, which is designed to deliver pharmaceuticals through the skin more effectively. Right to where treatment is needed most.
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Permetrex™ drives pharmaceuticals deep into the skin where their action is required – otherwise the drug remains in the outer layers of the skin.
So what makes Permetrex™ unique?
- It does not utilise chemicals which have a tendency to dry the skin and are therefore undesirable for diseases such as acne, psoriasis and atopic dermatitis;
- It creates substantial chemical potential when applied to the skin, which facilitates the rapid delivery of active pharmaceutical ingredients across the stratum corneum and into the lower layers of the skin;
- It can accommodate other chemicals which can selectively leave parts of the formulation on the skin in a protective coating for extended absorption and/or protection of the skin;
- Transdermal delivery avoids the ‘first-pass’ effect of liver metabolism, potentially enabling lower dosage levels of active pharmaceutical ingredients to be rapidly and reliably absorbed with high bioavailability.
Botanix is currently actively working with pharmaceutical partners who are using the Permetrex™ delivery system.