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LTS Lohmann Therapie-Systeme AG
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  5. LTS - Oral Thin Films for Fast Drug ...

LTS - Oral Thin Films for Fast Drug Delivery

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Oral thin film (OTF) technologies are designed to facilitate rapid drug delivery by placing the film on or under the tongue or buccally. The film quickly dissolves, allowing the active ingredient to be absorbed directly through the oral mucosa into the bloodstream. Ranging in size from 2 to 10 cm² and with thicknesses of 20 to 500 µm, these films offer a range of benefits. They enable fast onset of action, can improve bioavailability by circumventing the first-pass effect, and provide a convenient alternative to injectable medications. This technology is particularly beneficial for patients who experience difficulty swallowing, including those with conditions such as Multiple Sclerosis or ALS. The customizable release profiles of the drugs in OTF form add flexibility for pharmaceutical partners while enhancing compliance and convenience for patients. These films are easier for children, the elderly, and those requiring complex care, offering a discreet and water-free method of administration, ideal for use on the go.
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  • Improved compliance due to discreet and convenient application.

  • Fast relief from symptoms.

  • Can be taken without extra water.

  • Ideal for when patients are on the go.

  • Easier for children, older people and patients requiring complex care.

  • Ideal for patients who have difficulty swallowing.

 

  • Easy dosage with fast onset of action.

  • Possible avoidance of first-pass effect for improved bioavailability and saving costs for active substance.

  • Convenient alternative route for injectable active substances.

  • Drug release can be customized via different types of OTF LTS technologies.

  • Innovative and appealing form with design options for individual positioning.

  • Potential focus on patients with swallowing issues (e.g. Multiple sclerosis, ALS).

  • Life cycle management of established products.

 

OTF technologies – the ideal dose for fast delivery
Oral thin films (OTF) are placed on or under the tongue or buccally. They are immediately absorbed by the oral mucosa and the active substance is directly transported into the bloodstream. Our technologies enable fast release of the active substance, measure between 2 and 10 cm² and are extremely thin (20 to 500 µm). Forms can be a single-layer or multi-layer system, with the active substance able to be dissolved in the matrix, emulsified or dispersed. It can also be bound as a complex in order to mask taste, for example. Our partners are currently utilizing our OTF technology for therapies including opioid use disorder, pain management and vomiting/nausea.