Organovo - Bioprinting Process Tissues
Our bioprinting process starts with the identification of key architectural and compositional elements of a target tissue, and the creation of a design that can be utilized by a bioprinter to generate that tissue in the laboratory environment. The next step is to develop the bioprocess protocols required to generate the multi-cellular building blocks – also called bio-ink – from the cells that will be used to build the target tissue. While the bioprinting process is cell-agnostic, our bioprinted tissues utilize primary human cells where possible in order to produce the in vivo-like physiology most relevant for drug testing. We utilize multiple independent sources for our input cells to allow patient selection and high levels of diversity.
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The bio-ink building blocks are then dispensed from a bioprinter, using a layer-by-layer approach that is scaled for the target output. Proprietary biogels may be incorporated for temporary support or as filler to create channels or void spaces within tissues to mimic features of native tissue. The bioprinting process can be tailored to produce tissues in a variety of formats, including micro-scale tissues contained in standard multi-well tissue culture plates.
NovoGen Bioprinter® Platform
Our bioprinter technology has been used to create a spectrum of tissues: healthy liver, NASH liver, kidney, intestine, skin, vascular, bone, skeletal muscle, eye, breast and pancreatic tumor.
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