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Phage Display Antibody Library Synthesis Technology and Isolation Technology
Technology and knowledge on variable region amplification and optimal combinations of heavy and light chains: A high-quality library (MOURA library) consisting of 1011 diverse and functional clones, constructed by original gene amplification technology. Covering almost all antibody repertoires of individuals: Covers a wide repertoire of antibodies, including autoantibodies, using pre-B cells from bone marrow and spleen. Efficient phage antibody isolation technology - our IMPACT method: Our ideas and technologies have enabled efficient screening and isolation of phage antibodies against cell membrane antigens.
Human Health
Human Antibodies: hMOURA Library
A high-quality phage display antibody library with functionality and completeness covering the entire antibody gene of 1011 repertoires
Cancer cell-specific subset antibody library
hMOURA subset libraries (<106 size) after narrowing down against cell-surface antigens on 50 kinds of cancer cells. Enables efficient isolation of desired mAbs.
Camel Antibodies: cVHH MOURA Library
Single domain antibody library with the world’s largest diversity (1011 size), functionality and completeness
Animal Health
Canine Antibodies: cMOURA Library
Derived from our human antibody library. A canine antibody library with the world’s largest diversity (1010 size), functionality and completeness.
Feline Antibodies: fMOURA Library
Derived from our human antibody library. A feline antibody library (1010 size) with functionality and completeness.
Camel Antibodies: cVHH MOURA Library
Single domain antibody library with the world’s largest diversity (1011 size), functionality and completeness.
ANTITUMOR ACTIVITY SUPERIOR TO COMMERCIALLY AVAILABLE ANTIBODIES
EGF Receptor
In tumor-bearing mice, it showed a stronger tumor growth inhibitory effect than Cetuximab.
HIGH AFFINITY
TfR1
Anti-TfR antibody that currently has the strongest anti-cancer effect in the world (preparing to start human trials at other companies)
COMPLEX RECOGNITION
Integrin A6B4
World’s first anti-ITG A6B4 complex antibody
ANTIBODIES FOR LOW ANTIGENIC MOLECULES
CADM1/IgSF4
World’s first anti-CADM1 / IgSF4 human antibody