MammaTyper - Model PgR - Progesterone Receptor (PGR) Biomarker

The progesterone receptor (PGR) also belongs to the gene family of steroid receptors. Upon binding of progesterone, the receptor is activated and modifies expression of several downstream genes. Estrogen and progesterone receptors are found in Breast Cancer cells that depend on estrogen and related hormones (such as progesterone) to grow. All patients with invasive Breast Cancer or a Breast Cancer recurrence should have their tumours tested for estrogen and progesterone receptors. In case of cancers that are ESR1 and/or PGR positive, endocrine therapy blocks the tumour from using estrogen and/or progesterone, thus slowing or stopping tumour growth.