Nkarta, Inc.
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NkartaModel NKX019 - Proprietary CD19 Binder

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OX40 costimulatory domain, CD3ζ signaling moiety, membrane bound IL-15.

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For patients with many B-cell malignancies, there remains a substantial unmet medical need today.

  • Large opportunity remains despite approved autologous CAR-T products:
    • Gr3+ cytokine release syndrome (CRS): 13-49%
    • Gr3+ neurotoxicity: 18-31%
    • Limited number of specialized sites can treat
  • Compelling commercial opportunity