Miradx - Radiation Therapy Germ-Line Genetic Marker

Radiation therapy is a form of cancer treatment that is used in over 2/3 of cancer patients diagnosed every year. Although generally, radiation is a safe treatment, 5-10% of patients will experience serious side effects from treatment. In addition, some patients respond not only locally to radiation, but also have an immune response that can help them to fight their cancer. Miradx is at the forefront in this field, with a leading radiogenomics program, applying our class of microRNA binding site mutations to identify patients that respond differently to radiation. Our first publication on this problem found that patients with the KRAS-variant have a weak immune response to radiation, requiring the addition of cetuximab to help (Jama Oncology, 2016).