InSphero 3D InSight -Rat Islet Microtissues
A standardized in vitro rat islet model for translational diabetes studies and toxicity testing. InSphero 3D InSight™ Rat Islet Microtissues are currently in the final stages of product development and quality control testing. If you are interested in beta testing this product to help us further characterize the model and develop useful endpoints.
- Expand your GSIS assay window and improve sensitivity to insulin secretagogues with a long-lived, robust model persisting > 28 days in culture
- Use an in vitro model that reflects native rat islet biology with homogeneous islet size and cellular composition
- Increase efficiency by eliminating the need to hand pick islets, with microtissues available monthly and delivered assay-ready in a non-adherent 96-well plate
3D InSight™ Rat Islet Microtissues display stable viability, robust ß-cell function and optimal incretin response for more than 28 days in culture. Within each microtissue, the endocrine cells adopt a ß-cell core and the non-β-cell mantle architecture similar to native rat pancreatic islets. Uniform cytoarchitecture and functionality of rat islet microtissues enables simultaneous assessment of multiple endpoints (e.g. glucose-stimulated insulin secretion, total insulin and ATP content) in a one-islet-per-well format. The standardized islet size provides more uniform compound penetration and simplifies evaluation of changes in tissue size.
- Guaranteed 28 days viability
- 96-well format, 1 microtissue per well
- Produced on demand for beta testers