Ariana -Real World Data & Evidence (RWD/RWE) Platform

This extensive Real World Data & Evidence (RWD/RWE) capability underpins Ariana business services across:

• Precision medicine clinical development (for example, design of data-rich clinical protocols with synthetic control arms).
• Global health impact evidence generation (for example, epidemiological studies of specific diseases or industrial / environmental activities).

• High quality curated electronic health records (EHR) data collected during routine clinical care of patients have the potential to accelerate drug development
• In areas of high unmet need, real world controls could help provide external control for regulatory decision-making
• Requires advanced analytical techniques to address limitations pertaining to RW data (propensity scores)
• Real world patients » may be different to patients enrolled in clinical trials (with comorbidities, etc.) and use of RW data may provide a more accurate picture of the impact of a novel therapy

Ariana has implemented a sophisticated and customizable cloud analytics and reporting platform for evidence generation across these Real World databases:

• “Big Data” epidemiological studies of medico-economic impact of specific diseases or industrial / environmental activities
• Flexible analysis plan execution (including data exploration, data mining and multivariate analysis) over a wide range of spatial and temporal resolutions
• Platform is built using a combination of industry-standard (open) workflow, database, statistical and geo-mapping components, and proprietary data mining algorithms developed by Ariana. Publication track record in peer-reviewed manuscripts:
• Infectious disease epidemiology for quantification of disease burden, and comorbidity risk factors.