Immudex -SARS-CoV-2 Panels
Reliable Identification of SARS-CoV-2-Specific T-Cell Responses. T Cells Take the Lead in COVID-19. A deeper understanding of viral-specific T-cell responses to COVID-19 is needed to explore vaccine responses, long-term immunity, predict patients at risk, and even prepare for the next pandemic. T-cell responses are believed to be important for protection against severe disease through the development of long-term immunity. SARS-CoV-2-specific CD4+ and CD8+ T cells are present for at least a year after infection with COVID-19. Functional T cells targeting multiple antigens of SARS-CoV-2 are detected in mild and severe COVID-19, as well as asymptomatic individuals.
Understanding the specificity, frequency, and durability of the T-cell response is important for defining correlates of protective immunity and identifying
sub-populations eligible for re-vaccination.
Monitoring T-cell responses to a range of epitopes enables researchers to understand which viral proteins (e.g. spike, nucleocapsid) are preferentially targeted by T cells. This information is crucial for vaccine development and may uncover new targets for immunotherapy.
Dextramer® technology can help you characterize SARS-CoV-2- specific CD4+ and CD8+ T cells in blood, without missing rare or low-affinity cells, in an easy and reproducible way.
Monitor virus-specific T cells by flow cytometry using MHC I and II Dextramer® reagents, or choose dCODE Dextramer® reagents for NGS and single-cell multi-omics.
We provide pre-defined SARS-CoV-2 Dextramer® Panels, each with a curated selection of validated T-cell epitopes. Alternatively, select your own custom panel.
- MHC Dextramer® - for identification of antigen-specific T cells in blood by flow cytometry
- dCODE Dextramer® (HiT) - for bulk analysis of antigen-specific T cells by PCR and NGS
- dCODE Dextramer® (10x) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using 10x Chromium Single Cell analysis.
- dCODE Dextramer® (RiO) - for single-cell multi-omic analysis of antigen-specific T cells to combine information on TCR recognition, TCR sequencing, and gene expression using BD RhapsodyTM Single-Cell Analysis.
We want to share a curated list of validated epitopes shown to be recognized by T cells in COVID-19 patients.
These immunodominant SARS-CoV-2 specific T-cell epitopes are known to be present in large populations, based on publications and in-house knowledge.
Our scientists have found that many of these epitopes are conserved in Omicron and Delta variants, enabling researchers to monitor T-cell immunity across COVID-19 variants.
We hope this list helps you to select the most suitable epitopes for your SARS-CoV-2 specific T-cells research.