C-STEM -Scaling-Up Cell Therapy Technology
Scale-up
C-Stem generates scale-independent cell culture micro-environments, allowing to progress to larger bioreactors without changing key parameters.
Safety
C-Stem perserves genomic integrity and yields mature cell phenotypes, thereby enhancing the safety of cellular products
Efficacy
C-Stem delivers functional microtissues, which were shown to improve graft integration and reduce time-to-effect.
#1 INDUSTRIAL-GRADE MICROFLUIDICS
High-throughput stem cell encapsulation
- Automated encapsulation device
- Closed, single-use, cGMP compatible process
- Throughput: > 1,000 capsules per second
- C-Stem high throughput stem cell encapsulation
- ips cell encapsulation biomimetic 3D stem cell micro-environment
#2 BIOMIMETIC 3D MICRO-ENVIRONMENTS
Self-organization in in vivo-like stem cell microtissues
- Epiblast structure promotes fast & high-fidelity cell division
- Capsule lets nutrients, gas and growth factors in & out
- Capsule protects cellular content from mechanical stress
#3 BIOREACTOR SCALE-UP
Exponential stem cell expansion & differentiation in bioreactors
- >100-fold hPSC amplification per week
- Best-in-class cell viability, pluripotency & genomic integrity
- Single-batches of over 10 billions cells in 10L bioreactor
- Differentiation into functional microtissues in bioreactor
#4 EASY DOWNSTREAM PROCESSING & DELIVERY
Functional 3D microtissues ready for transplantation
- Capsule removal in minutes to release cell content
- Mature cell phenotypes enhance product safety & efficacy
- 3D microtissue format facilitates handling & delivery
Our job: to bring the benefits of C-Stem™ as fast as possible to patients through in-house and co-development programs
Adapt 2D to 3D
A 3D stem cell biology team with a dedicated R&D platform adapts existing protocols to C-Stem™ for optimal hPSC amplfication and differentiation
Scale-up early
A bioproduction team develops bioreactor-based manufacturing processes to secure commercial-scale batches for non-clinical and early clinical phases
Enhance delivery
Our scientists bring expertise in logistics, delivery formats and medical devices to maximize the clinical convenience and therapeutic benefits of the product
Optimize manufacturing
Our encapsulation and analytical development teams provide continuous support for the optimization of manufacturing processes