Seno Medical - Opto-Acoustic Imaging Device
Opto-acoustic imaging looks for the presence of tumor neoangiogenesis, new blood vessels produced by malignant tumors to help supply nutrients to and remove wastes from the tumor. Malignant masses cannot grow larger than 2-3 mm without generating neovessels. The Seno laser wavelengths used were selected to enable visualization of relative amounts of oxygenated and deoxygenated hemoglobin within the vasculature and within masses and their surrounding tissues. Inside vessels supplying and draining a malignant tumor, the hemoglobin gives up its oxygen to the rapidly growing cells and becomes deoxygenated.
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The combination of hemoglobin concentration and its relative oxygenation has been shown to have good diagnostic accuracy (Academic Radiology 2005; 12:925-933).
- Malignant tumors have increased blood (hemoglobin) concentration with relatively decreased oxygen content.
- Benign growths have variable blood (hemoglobin) concentration with relatively more oxygenation.
Functional information has direct relevance to tumor pathophysiology and supports a clinician’s decision-making as to a lesion’s malignancy and the need for breast biopsies.
Opto-acoustic imaging may permit the identification of tumors as small as 3 mm and has demonstrated the ability to see submillimeter vascular structures. Early detection is important, because biologically advanced tumors are more capable of metastasis.
Opto-Acoustic Advantages
Seno Medical’s Imagio® breast imaging system has the potential to provide physicians with vital information needed to better determine whether a suspicious mass is cancerous with the goal of reducing the rate of negative breast biopsies. Each year in the U.S., 1.6 million women undergo core needle or surgical breast biopsies after a suspicious mass is found through breast imaging or self-exams.1 However, more than 80 percent of these breast biopsies reveal benign pathology.2
Seno’s opto-acoustic technology fused with ultrasound (OA/US) may reduce negative breast biopsies by combining laser optics and acoustics, providing radiologists greater confidence to confirm or rule out malignancies better than they can with ultrasound alone.3
Seno Medical’s Imagio® breast imaging system has the potential to provide physicians with vital information needed to better determine whether a suspicious mass is cancerous with the goal of reducing the rate of negative breast biopsies. Each year in the U.S., 1.6 million women undergo core needle or surgical breast biopsies after a suspicious mass is found through breast imaging or self-exams. However, more than 80 percent of these breast biopsies reveal benign pathology.
Seno’s opto-acoustic technology fused with ultrasound (OA/US) may reduce negative breast biopsies by combining laser optics and acoustics, providing radiologists greater confidence to confirm or rule out malignancies better than they can with ultrasound alone.
The process starts by using laser light of two specific wavelengths to microscopically expand the affected cells, creating a soundwave that can be ultrasonically detected and registered.
Signals from the sensors are analyzed and co-registered into images that present a real-time blood map of the lesion in striking color. OA image contrast is related to both blood volume and oxygenation status.
In general, malignant masses are more vascular and deplete oxygen from the blood at a higher rate than do benign masses.
Blood within and around masses preferentially absorbs the light over normal tissue and becomes slightly heated. A transient thermoelastic expansion causes a tumor to emit a pressure or acoustic wave. This acoustic wave is then detected by sensors within the hand-held, opto-acoustic (OA) probe as it is positioned over the indicated area of the breast.
Signals from the sensors are analyzed and co-registered into images that present a real-time blood map of the lesion in striking color. OA image contrast is related to both blood volume and oxygenation status.
In general, malignant masses are more vascular and deplete oxygen from the blood at a higher rate than do benign masses.
The two wavelengths of laser light that are used in the Imagio® OA system facilitate imaging by showing the relative differences between oxygenated and deoxygenated blood.
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