Skimune - Sensitisation & Immunotoxicity Testing
From Immunotoxicity Testing Platform
Our human tissue explant assay for the detection and characterisation of adverse immune reactions in vitro. Helping you characterise immune reactions to your novel chemicals, pharmaceuticals, biologicals and cellular therapies.
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Overview of Skimune
- Histopathological analysis is performed on the skin, and damage graded from I-IV
- ELISA/ multiplex MSD/ Luminex analysis of culture supernatants
- qPCR / mRNA expression
- High throughput RNAseq analysis
- Immunohistochemistry
Skimune assay
What you may not have known is that Alcyomics’s Skimune® assay is a human tissue explant assay which includes activated autologous dendritic cells and T-cells to measure T-cell proliferation and cytokine release alongside tissue specific damage assesment.
We have developed our assay to test for sensitisation and immunotoxicity in the skin and as a test for more general systemic immune responses.
Our assay can characterise immunological reactions in a wide range of applications such as chemicals, cosmetics, pharmaceuticals, cellular therapies and biologicals (monoclonal and Bispecific antibodies). Our assay has been widely published and validated to give you clinically relevent insights into the immunotoxiciy characteristics of your test articles. Get in touch to find out more!
We have developed our assay to test for sensitisation and immunotoxicity in the skin and as a test for more general systemic immune responses.
Our assay can characterise immunological reactions in a wide range of applications such as chemicals, cosmetics, pharmaceuticals, cellular therapies and biologicals (monoclonal and Bispecific antibodies). Our assay has been widely published and validated to give you clinically relevent insights into the immunotoxiciy characteristics of your test articles. Get in touch to find out more!
Benefits of Skimune are:
- Primary human tissue-based from varied donors, allowing for a more detailed understanding of immunotoxicity across age groups, sex and other demographics.
- Does not rely on 2D cultures of cells.
- Our dynamic assay is capable of a wide array of readouts. Specifically, Skimune® can cover both key event 2, 3 and 4 in the sensitisation pathway (Figure 3).
- Saves time and money in product development compared to other available tests.
- Capable of distinguishing the type of hypersensitivity reaction.
- Validated to be sensitive against: Chemicals, Complex formulations,? Cosmetics, Biologicals, Cellular Therapies and many more.
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