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SystImmune -Model BL-B01D1-ADC -Specificity Enhanced Bi-specific Antibody (SEBA) Molecules

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Built on the foundation of Specificity Enhanced Bi-specific Antibody (SEBA) molecules the SEBA-ADC have an advanced mechanism of action. This advanced functional class is referred to as Heterogeneity overcoming - Immunogenic death inducing - Resistance antagonizing - Enhanced Specificity (HIRE) molecules that target cancer cells. While HIRE molecules provide cancer cells specific targeting, and exert bi-modal proliferative inhibition, any cancer cell clones attempting proliferative escape are exposed to topoisomerase inhibition and die when attempting to duplicate.
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The tetravalent HIRE BL-B01D1 has two binding domains for distinct Growth Factor Receptors that drive cancer cell proliferation and survival. Inheriting the SI-B001 mechanisms of action, BL-B01D1 blocks EGFR and HER3 signals to cancer cells, reducing proliferation and survival signals.  Upon antibody mediated internalization, BL-B01D1 is trafficked to cancer cell lysosomes and liberates its therapeutic payload that induced genotoxic stress activating pathways leading to cancer cell death.  

BL-B01D1 is currently being evaluated as a single agent in clinical trials enrolling patients with a variety of EGFR+ and HER3+ solid tumor indications.