
NCr nude -Model NCr nude -Spontaneous Mutant Model
Origin: Taconic received the NCr nude Spontaneous mutant model from NCI in 1993 after several years of random breeding. The mice were derived by hysterectomy to achieve germ-free status prior to introduction into Restricted Flora™ IBU™ colonies. These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background.
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bone marrow cell
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immunodeficiency
paralysis
hysterectomy
- Outbred background originated from an accidental cross between the BALB/c inbred nude and NIH(S) outbred nude mice
- The standard athymic model for National Cancer Institute (NCI) studies as well as many pharmaceutical and institutional oncology screening programs
- The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues.
- Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. Heterozygous nudes were originally thought to have normal immune systems, but in fact have immune alterations such as reduced bone marrow stem cells and lower thymus weights. Heterozygous nudes may thus not be appropriate for use as sentinels. They may be used in PK/dosing studies.
- Paralysis does seem to be a phenotype of NCR nude mice, however in measuring this phenotype in our colonies it is present in less than .04%
Genetic Background: Ncr Background
Coat Color Loci: Tyrc
Color: Albino (sp/sp nude|sp/wt haired)
Species: Mouse
Animal Diet: NIH #31M Rodent Diet