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ExcellGeneModel SARS-CoV-2 - Stabilized Delta Trimeric Spike Protein for Delta Variant

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The Delta variant of SARS-CoV-2 was first detected in India and has, by November 2021, spread to over 179 countries. It contains again the 614G mutations and others, notably a proline to arginine substitution that may facilitate the cleavage of the S precursor into the S1/S2 conversion, which results in the fusion of the spike protein with the cell membrane receptor ACE2.

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  • Sequence modifications C-terminal Transmembrane region replaced with a trimerization domain and a polyhistidine tag. Two stabilizing proline mutations. Scrambled S1/S2 furin cleavage site. D614G amino acid change.
  • Isolate (Seq ID) 20A/S:478K
  • Expression system CHOExpressTMcells
  • Purity > 95 % as determined by SDS-PAGE.
  • Buffer 0.01M PBS, pH 7.4, no preservatives
  • Availability mg to grams