Stemedica - Allogeneic Progenitor Cell
There are two types of cells currently used for investigating progenitor cell therapies for degenerative diseases: autologous and allogeneic. Autologous progenitor cells are derived from the patient being treated. They are retrieved surgically, expanded, and transplanted back into the same patient. Allogeneic progenitor cells are derived from healthy volunteers or organ donations. These cells are expanded and stored for future use in multiple medical conditions.
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Stemedica’s allogeneic progenitor cell produ...
Stemedica’s allogeneic progenitor cell products have the following competitive advantages :
Reproducibility: Stemedica can currently produce more than 450,000 doses of itMSCs from an individual donor and 180,000 doses of itNSCs from a different donor, while maintaining strict manufacturing control over cell quality and performance.
Immune Privilege: Autologous cells are considered more immune privileged because they are derived from the same organism which receives the stem cells, thus avoiding the likelihood of an immune response. In contrast, the main cause of rejection and clearance of allogeneic stem cells is from the host expressingHLA-DR receptors on the cell surface, which can lead to an immune response from the host organism. Stemedica is growing itMSCs and itNSCs under low-oxygen conditions; this reduces the presence of HLA-DR to less than 2 percent, therefore reducing the chance of an immune response.
Cost: Autologous stem cell therapy is much more expensive than allogeneic therapy. Allogeneic cells are available off-the-shelf and already tested, but autologous cells must be retrieved from the patient by invasive surgical procedure, tested, expanded individually and, finally, re-introduced into the patient.
Scalability: Stemedica’s itMSCs and itNSCs are highly scalable with hundreds of thousands of treatment doses deriving from a healthy donor sample. Autologous cells are not scalable because they need to be retrieved surgically from each individual patient.
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