Synovasure - RISC Panel
Arthritis is one of the most prevalent conditions affecting nearly 1 in 4 adults in the United States. In addition, significant medical costs, as well as potential for lost wages are not uncommon with arthritis1 making an accurate and timely differential diagnosis key to potentially providing targeted conservative care and treatment to patients with knee joint pain.
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At CD Laboratories, we offer the first-of-its-kind – offering a one stop, comprehensive panel of synovial fluid laboratory tests to aid in differentiating common arthritis conditions in the knee including:
- Native Septic Arthritis (NSA)
- Osteoarthritis (OA)
- Rheumatoid Arthritis (RA)
- Crystal Arthritis
The Synovasure RISC Panel includes synovial fluid testing for native septic arthritis through white blood cell (WBC) count with differential.
If cell count is >3,000 or PMN% >70%, specimens are reflexed for:
- Synovasure Alpha Defensin for NSA (alpha defensin and lactate)
- Synovasure Microbial Identification
- Culture
First-of-its-kind laboratory test to aid in the diagnosis of isolated, idiopathic OA via synovial fluid assessment:
- Cartilage Oligomeric Matrix Protein (COMP) – Protein biomarker of cartilage breakdown shown to have elevated concentration in the presence of OA2,3
- Interleukin-8 (IL-8) – Molecule that attracts and activates neutrophils shown to have elevated concentrations in cases of inflammatory arthritis (ie. RA or gout)4,5
COMP/IL-8 ratio is utilized to aid in differentiating between primary and secondary OA.
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