SynTumor - 3D Cancer Model
From 3D Tissue and Organ-on-Chip Models
SynTumor is a 3D tissue model for real-time visualization and quantitative assessment of cell-cell and cell-drug interactions in a physiologically and morphologically realistic tumor microenvironment. The system enables (a) circulation in the microvasculature, (b) transport across the vessel walls, and (c) delivery to the tumors. Starting with scans of vascular networks incorporated with interstitial and tissue/tumor spaces, the SynTumor 3D tissue model creates an in-vitro tumor microenvironment akin to a viable histological slice.
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The SynTumor 3D Cancer model has the following ben...
The SynTumor 3D Cancer model has the following benefits:
- Side by side architecture enables quantitative real-time visualization
- Physiological leaky vasculature with engineered porous structures
- Morphologically realistic in vivo based architecture
- Physiologically realistic convective and diffusive transport
- Microfluidic platform with ultra-low consumable volumes
PRODUCT PURCHASING OPTIONS
Chips: Depending on your specific research applications you can select from the idealized IMN2 (radial or linear) or microvascular (SMN2) network chip configurations in single or multi-chamber formats. Chips can be selected based on whether 2D (IMN2, SMN2 chips) or 3D (IMN3, SMN3 chips) tumor growth is needed. Additionally, chips with multi-chambers are also available.
Kits: All the basic components required to run SynTumor assays can be purchased in a kit. Two Kit formats are available.
Starter Kit: Select this for your first-time purchase
- 10 SynTumor chips (Choice of IMN2 radial, IMN2 linear or SMN2 microvascular network chips)
- Accessories including tubing, clamps, needles, and syringes
- Pneumatic priming device (required for priming tubing to remove air)
Assay Kit: Select this kit format if you have previously purchased the pneumatic priming device
- 10 SynTumor chips (Choice of IMN2 radial, IMN2 linear or SMN2 microvascular network chips)
- Accessories including tubing, clamps, needles, and syringes
Schematics of the devices used to develop tumor on a chip models. Apical chamber (outer channels-blue) are for culture of vascular (endothelial cells) while basolateral chamber (central chamber-red) are for culture of tissue, stromal or immune components. Porous architecture enables communication between the vascular and tissue cells.
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