T-cell Proliferation & Cytokine Analysis
From Immunotoxicity Testing Platform
Assessment of immune activation: Alcyomics has a wide range of cell phenotypic services for your research needs, to benefit both drug discovery and validation. With our in-house state-of-the-art instrumentation, we can analyse and deliver accurate analyses of T-cell proliferation responses and perform multiplex cytokine analysis. This screening test can be used in conjunction with the Skimune® assay to determine adverse immune or allergic reactions to drugs and compounds in both the autologous and allogenic immune settings.
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We have employed T-cell proliferation and multiplex cytokine analysis to successfully predict immune responses and assess mode of action of compounds.
Our T-cell proliferation and multiplex cytokine assays provide a fast and high-throughput testing platform to help predict adverse immune responses to your development compounds at a competitive price.
Our T-cell proliferation and multiplex cytokine assays provide a fast and high-throughput testing platform to help predict adverse immune responses to your development compounds at a competitive price.
T-cell proliferation responses can provide valuable insight into how your compound is behaving when introduced to the human immune system.
Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. An In Vitro human skin test for assessing sensitizing potential. Journal of Applied Toxicology. 2016:36 (5), 669-684. DOI: 10.1002/jat.3197
Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, Dickinson AM. An In Vitro human skin test for assessing sensitizing potential. Journal of Applied Toxicology. 2016:36 (5), 669-684. DOI: 10.1002/jat.3197
Benefits of T Cell Proliferation are:
- High throughput, multiple compounds and multiple donor population studies
- Matched donor/tissue testing
- HLA testing available
- Perfect screening assay for Skimune®
Multiplex cytokine analysis of cell culture supernatants can further confirm activation of the human immune system and give insight into the mode of action of your test compounds. Th1 & Th2 responses associated with cytotoxic, eg IFN? & TNF-α, or allergic responses, eg. IL-4 & IL-13, can be assessed using this platform
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