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Toluenesulfonylmethyl IsocyanidE (TOSMIC)

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Other names: tosylmethyl isocyanide, p-Toluenesulfonylmethylisocyanide, TosMIC. Molecular weight: 195.24. Appearance: colorless crystalline powder, off-white to yellowish. CAS#: 36635-61-7.

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Used as an intermediate for various reasons, including in the Van Leusen reaction which is used to convert aldehydes to nitriles or in the preparation of oxazoles and imidazoles.

Three of TosMIC’s mission-critical industrial applications are:

  1. To convert carbonyl groups to nitriles as a cyanating reagent
  2. To synthesize heterocyclic compounds such as oxazoles, imidazoles and pyrroles
  3. To prepare Knoevenagel-type condensation products

  • Pharmaceutical
  • Agriculture
  • Food
  • Electronics

Varsal is one of the world’s leading producers of TosMIC, and one of the few producers capable of producing large-scale, pharma-grade material. Varsal’s proprietary manufacturing and treatment process allows it to produce extremely high purity material with low residual impurities, low loss on drying, and low residue on ignition, leading to maximal yield and product quality for Varsal’s customers.