Pamorelin - Triptorelin - Gonadotropin Releasing Hormone (GnRH)

Triptorelin is a gonadotropin releasing hormone (GnRH) agonist; Triptorelin, the active substance of Decapeptyl/Trelstar/Pamorelin/Triptodur, is a GnRH agonist analogue. An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Triptorelin decreases the serum testosterone to castrate levels (estradiol in females). Androgen deprivation stops the growth of the androgen dependent prostate cancer, alleviating pain and improving thus the quality of life of patients. GnRH agonist treatment achieves similar overall survival rates in advanced prostate cancer as surgical castration.The triptorelin 1-month, 3-month and 6-month sustained release formulations have provided patients with a convenient treatment modality.