Vivotif - Typhoid Vaccine

Vivotif is manufactured by the PaxVax Berna GmbH, Switzerland. The vaccine strain is grown in fermentersundercontrolled conditions in medium containing a digest of yeast extract, an acid digest of casein,dextroseand galactose. The bacteria are collected by centrifugation, mixed with a stabilizer containing sucrose,ascorbic acid and amino acids, and lyophilized. The lyophilized bacteria are mixed withlactose andmagnesium stearate and filled into gelatin capsules which are coated with an organic solutionto renderthem resistant to dissolution in stomach acid. The enteric-coated, salmon/white capsules arethenpackaged in 4-capsule blisters for distribution. The contents of each enteric-coated capsule are shown inTable 1.