IGeneX - Model COV5T SARS-CoV-2 - Vaccine Response Test Panel
IGeneX is now offering the COV5T SARS-CoV-2 Vaccine Response Test Panel, which tests for antibody response and T-cell response. This comprehensive test panel gives patients the ability to monitor their overall response to the vaccine.
COVID-19 vaccines are designed to provoke a strong response to the most dangerous elements of the coronavirus, called spike proteins. There are three possible immune responses generated by a successful vaccine: the production of B cells or T cells — or both.
The test panel consists of two SARS-CoV-2 ImmunoBlot tests (one for IgM, one for IgG), and a SARS-CoV-2 IgXSpot test. ImmunoBlots measure antibody response from activation of B cells, and IgXSpot measures T-cell reactivity.
B CELLS
Antibodies produced by B cells attack the virus directly. Ideally, antibodies would be active for a long time, but studies so far indicate that COVID-19 antibodies are relatively short-lived. This response is similar to that seen for other types of coronaviruses, such as the common cold or influenza.
T CELLS
The second line of defense is provided by T cells. Unlike B cells, T cells do not attack the virus directly, but instead target infected cells — thus stopping the virus from reproducing. Recent data indicate that T cells have the ability to provide longer-term protection against COVID-19.
The COV5T SARS-CoV-2 Vaccine Response Panel measures immune response from all vaccines, including Pfizer, Moderna, Johnson & Johnson. Positive test results, however, do not guarantee immunity from COVID-19. Results should be used in conjunction with advice from your doctor. The information will be helpful in determining the following:
- Is my body producing antibodies?
- Are my t-cells activated?
- Am I seronegative?
- Am I protected from others?
- Are others protected from me?
- Do I have natural immunity?