Affinity Maturation Services
Quick in-silico antibody affinity maturation based on antigen/antibody interface analysis, application of Ab Studio’s unique biochemical filter and on-bench verification.
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Servcies Overview
Build up the model for antigen/antibody complex
The antigen/antibody model is built using AlphaFold, the most advanced artificial intellegence software for protein modeling.
Analysis of interface residues
The established antigen/antibody complex allows for the detection of interface residues. With expertise in antibody design, appropriate residues will be chosen to undergo affinity maturation.
Affinity maturation calculations
Biophysical calculations will dictate the first level of the affinity maturation design. Then, Ab Studio’s unique biochemical filter will be applied to complete the design.
On-bench verification
All designs will be verified through cell binding, ELISA, or biolayer interferometry (BLI) methods.
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