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Antibody Engineering Service
Fluidic Sciences Ltd. offers the Fluidity One-M instrument, integrated with Microfluidic Diffusional Sizing (MDS) technology, specifically engineered for in-solution analysis of antibodies and their targets throughout various stages of development. The device is designed to ensure stability optimization, target specificity, and modulation of immune responses necessary for therapeutic antibodies, which are widely used in oncology, neurology, and immunology. This instrument's capabilities include the measurement of antibody size changes, affinity assessments, and competition experiments to study ternary complexes. It accommodates diverse sample types, including buffers, serum, and lysates, making it adaptable to various stages of drug formulation and biofluid analysis. Accompanied by the Fluidity Insight smart assistant, guided by advanced machine learning, it assures precise guidance during experimental procedures to deliver robust data consistently. This technology is crucial for the effective analysis of monoclonal and bispecific antibodies' interactions with epitopes in real-world environments.
The making of therapeutic antibodies
Antibodies represent one of the most prevalent therapeutic approaches, with a wide range of variations available to optimize function across oncology, neurology, and immunology. The successful transition from development to clinical application of antibodies depends on optimizing antibody stability, target specificity, and the ability to modulate immune responses.
Achieving this requires simultaneous engineering of a candidate’s stability and affinity against its target and other components of the immune system. The study matrix changes through the drug development pipeline, from simple buffers to biofluids and finally to the adjuvant-heavy buffers used in formulation.
The technology used for the assessment, therefore, needs to be robust and flexible for diverse types of interactions, diverse types of samples (purified or non-purified, in buffers or in serum, lysate or feedstock) and have built-in quality control features to ensure a streamlined measurement process across all stages of antibody development.