Biofilm Testing and Antimicrobial Efficacy Service
iFyber provides a suite of biofilm tests to verify the efficacy of antimicrobial medical devices and drugs. Biofilms are complex communities of microbes protected within a matrix of sugars, proteins, and extracellular DNA. These characteristics, in addition to their tolerance to antibiotics, make biofilms significantly more difficult to prevent and remove. Research has shown that between 60 to 90% of chronic wounds are associated with biofilms. The development of technologies to combat resistant biofilm infections often requires custom biofilm test models. Biofilm tests at iFyber can be tailored to evaluate technologies in a way that meets the client’s objective.
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We focus our biofilm testing on determining the ef...
We focus our biofilm testing on determining the efficacy of new technologies and actively developing novel assay systems based on our client’s specific needs. Initial in vitro test methods can be used to screen formulations and measure antimicrobial and anti-biofilm efficacy for a range of applications, from therapeutics to antifouling technologies. For wound care applications, our ex vivo model allows for the evaluation of prototype formulations on a more clinically relevant matrix before the start of costly in vivo animal studies – saving money and reducing time to market. In addition to our standard and custom biofilm testing program, iFyber also offers a host of antimicrobial susceptibility testing options for planktonic (free-floating) bacteria. Biofilms continuously shed planktonic bacteria that can disperse and attach to other areas of the wound, potentially forming new biofilms. By taking a multi-method biofilm testing approach, treatments can be evaluated for their ability to both prevent the formation of biofilms and eradicate existing biofilms.
Examples of relevant materials for biofilm testing include new antibiotics/biocides, coatings, nanomaterials, wound dressings, coated natural tissue matrices, and coated medical devices. In addition to custom testing solutions, iFyber offers GLP-compliant testing services.
- MBEC in vitro biofilm test system
- Microwell biofilm susceptibility and eradication assays
- Porcine dermal explant ex vivo model
- Artificial sputum in vitro model of cystic fibrosis
- Modified Robbins device
Antimicrobial Susceptibility Testing
- Dynamic contact assay
- Time-kill assay
- AATCC Test 100
- Zone of inhibition assay
- Time course of antimicrobial activity
- MIC assay
- MTT assay
- Bacterial selective plating
- Bacterial attachment
- Simple staining for bacteria (e.g., methylene blue, safranin, crystal violet)
- Differential staining (e.g., Gram staining, GMS staining)
- LIVE/DEAD staining
- Confocal microscopy and 3D reconstruction for ex vivo modelGLP and Non-GLP slide scanning
- Visualization of bacteria using GFP or luciferase (lux) reporter systems
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