CD Formulation -Calcitonin Long-acting Extended Release Microsphere Preparation
FromCD Formulation
Calcitonin Long-acting Extended Release Microsphere Preparation: By adding large acidic substances such as dextran carboxylic acid (DEX-COOH) and slow-release polymers such as polyhydroxyacetic acid (PLGA), the local acidic environment caused by the degradation of the above-mentioned reagents can be used to achieve a sharp release of calcitonin within a certain time frame, solving the problem that calcitonin is difficult to be released within the slow-release polymer material. The rapid release period of calcitonin microspheres can be adjusted by the slow release polymer used. The development of calcitonin long-acting sustained release combination microspheres overcomes the disadvantages of protein peptide drugs that are easily adsorbed in the sustained release material and cannot be released; it achieves sustained release with small abrupt release and complete release.