MtoZ Biolabs -Model analysis-of-molecular-size-variability-based-on-ce -CE-SDS Based Molecular Size Variation Analysis Service
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: marketing@mtoz-biolabs.com
Aggregation or fragmentation of protein molecules primarily causes variations in molecular size, impacting their biological activity, stability, and their efficacy and safety as pharmaceuticals. In the development and production of biopharmaceuticals, even slight variations in molecular size can reduce drug efficacy or pose safety risks. Thus, precise detection and analysis of these variations are crucial for bioproduct characterization. Capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) uses an electric field to drive charged particles through a capillary, facilitating the separation and identification of proteins or peptides. By incorporating SDS, a surfactant, proteins acquire a negative charge and can be sorted by molecular size. CE-SDS combines the separation efficiency of electrophoresis with the precise measurement capabilities of SDS-PAGE, suitable for analyzing both individual and complex protein mixtures.
The CE-SDS-based analysis of molecular size variability is noted for its high resolution, sensitivity, and automation. This technique is extensively applied in the assessment of protein purity, molecular size determination, aggregation or fragmentation detection, disease diagnostics, and biopharmaceutical applications. It is of great importance in new drug development, protein function research, and biopharmaceutical quality control. MtoZ Biolabs has developed an integrated physicochemical analysis and structural characterization platform that facilitates the separation and comprehensive characterization of molecular size variants. Whether you are interested in protein fragments, conjugates, or aggregates, MtoZ Biolabs offers accurate, efficient, and all-encompassing solutions. Free consultations are available for further information.
In the technical report, MtoZ Biolabs will provide you with detailed technical information, including:
1. Experimental Procedures
2. Relevant Experimental Parameters
3. Detailed Information on CE-SDS-Based Molecular Size Variability Analysis
4. Electrophoresis Images
5. Raw Data