Early Detection of Lung Cancer
EarlyCDT is a simple blood test that detects the elevated presence of autoantibodies generated by the body's immune system as a natural defence against cancer cells. EarlyCDT Lung is the world’s most thoroughly validated blood test for the detection of lung cancer and requires only a small volume of blood which can be taken in the community setting as well as a doctor’s surgery. Shown to detect lung cancer on average four years earlier compared to current standard clinical diagnosis, EarlyCDT Lung can also provide an effective assessment of cancer risk in indeterminate pulmonary nodules (IPNs).
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80% of lung cancer cases are diagnosed in the latest stages of the disease.
EarlyCDT Lung is a simple blood test to identify people with a heightened risk of lung cancer for triage into CT scanning.
A finger prick or blood draw can be collected in the community, GP or hospital setting.
EarlyCDT Lung can detect lung cancer on average four years before standard of care [1] and has shown in a large NHS trial that it can reduce late stage lung cancer presentation by 36% [2].
The ECLS trial
The Early detection of Cancer of the Lung Scotland (ECLS) trial conducted in Scotland with 12,208 patients, is believed to be the largest randomised controlled trial using blood biomarkers for the detection of lung cancer.
Results demonstrate the potential of Oncimmune's EarlyCDT Lung blood test to reduce the incidence of patients with late-stage lung cancer at diagnosis, compared with standard clinical diagnosis.
In a randomised controlled trial of 12,208 people in Scotland at high risk of developing lung cancer, it was shown that more people were diagnosed at an early stage of the disease in the two years after having the EarlyCDT Lung blood test than those in the control arm who received standard clinical care.
The findings, presented at the 2019 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (IASLC) in Barcelona, are an important validation of Oncimmune's diagnostic platform technology which harnesses the power of the immune system, to detect evidence of the body's natural response to cancer. The technology can detect cancer on average four years before standard clinical diagnosis.
Lung cancer was chosen as the first target of the technology because it is the world's leading cause of cancer-related death and is often detected at an advanced stage with approximately 85% of patients in the UK undiagnosed until the disease has spread to other parts of the body.
Among those people who received the EarlyCDT Lung test and went on to develop lung cancer within the next two years, 41.1% were diagnosed at an early stage (stage 1&2) of the disease, compared with 26.8% among the control group subject to standard clinical practice. This resulted in a 36% reduction in late stage presentation after 2 years of follow up in subjects randomised to the EarlyCDT blood test.
The trial also showed a lower rate of deaths among people in the intervention arm of the trial after two years compared with people in the control group. Lung cancer-specific deaths were also lower in the intervention group. This suggests that the EarlyCDT Lung blood test followed by CT imaging could produce a mortality benefit, although the trial was not powered to demonstrate such a trend after two years.
The results further validate the use of Oncimmune's platform technology as a screening modality, which can detect cancer four years or more before standard clinical diagnosis. Oncimmune's patented technology works by detecting the presence of autoantibodies generated by the body's immune system as a natural defence against cancer cells.
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