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Gene Therapy Drug Research & Development
FromPace Analytical
In early-phase gene therapy development, we work with you to determine the most reliable analytical methods to provide the data needed to guide effective development decisions. Next, we deliver a robust assessment of the physicochemical and biophysical characteristics of the therapeutic molecule.
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Often, this may include a sub-set of attributes:
- Determination of molecular weight (DNA / RNA)
- Conformation of nucleic acids
- Thermal and chemical stability
- Determination of molar extinction coefficient
- Capsid integrity and protein composition
- Lipid Nanoparticle (LNP) composition and size distribution
- Encapsulation efficiency (LNP / VLP)
Often, this may include a sub-set of attributes:
- Determination of molecular weight (DNA / RNA)
- Conformation of nucleic acids
- Thermal and chemical stability
- Determination of molar extinction coefficient
- Capsid integrity and protein composition
- Lipid Nanoparticle (LNP) composition and size distribution
- Encapsulation efficiency (LNP / VLP)