Heart Failure with Reduced Ejection Fraction (HF-rEF)

HFrEF occurs when the left ventricular ejection fraction (LVEF) is 40% or less and is accompanied by progressive left ventricular dilatation and adverse cardiac remodelling. Worldwide, the burden of heart failure has increased to an estimated 23 million people, and approximately 50% of cases are HF-rEF. Despite several therapeutic options, heart failure with reduced ejection fraction remains a significant burden on economy and healthcare with persisting high mortality and hospitalisation rates. Thus unmet need for new therapies in the treatment of heart failure with reduced ejection fraction remains thus very high.