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Alfa Chemistry - Hydrocortisone ...

Alfa Chemistry - Hydrocortisone Butyrate

Hydrocortisone butyrate is a synthetic glucocorticoid. Binding and activation of the glucocorticoid result in the activation of lipocortin that inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, a precursor for inflammatory mediators prostaglandins and leukotrienes, thereby inhibiting inflammation. In addition, glucocorticoid also stimulates lipocortin-1 release into the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammations.