Induction of Transporters Services

The new FDA draft guidance suggests that inducers of transporters be identified during drug development. The guidance states “activation of nuclear receptor assays may be used as an initial evaluation of the induction potential of an investigational drug on transporters”. To that end, Puracyp has developed nuclear receptor activation technology for monitoring P-glycoprotein induction. Assays available include CAR and/or PXR activation to identify compounds that induce P-glycoprotein.