Infectious Diseases Treatment
Infectious diseases, caused by pathogenic micro organisms, such as bacteria, viruses, parasites or fungi, are responsible for millions of deaths globally each year. Vaccines are estimated to save millions of lives each year. In addition to eradicating two naturally occurring diseases, global vaccination has significantly reduced the incidence of many others (in many cases it is estimated by over 90%).
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However, despite this track record of success, vaccination remains relatively underutilised.
Through our collaborations, we have focused on developing novel solid dose formulations of existing vaccines and exemplified the potential value of our ImplaVax® technology for improving vaccination by completing successful studies in several infectious diseases, including seasonal/pandemic influenza and diphtheria.
Potential dose and regimensparing were noted in all studies, with enhanced immune response seen compared to commercial vaccines, producing potentially protective antibody responses after a single dose of the ImplaVax® vaccine.
We expect that the use of ImplaVax® solid dose formulations will lead to an increased uptake in vaccination, due to this strong potential for regimen sparing (as one dose only can deliver both ‘Prime’ and ‘Booster’ inoculations) as well as the the strong patient preference for needle-free vaccination. In our first human factors study, we found that the ImplaVax® platform was preferred (93%) by all groups of administrators, recipients and parents in comparison to a standard needle and syringe injection.
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