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creative biogene - Integrase-Deficient ...

creative biogene - Integrase-Deficient Lentivirus

Lentiviruses are powerful tools that have been widely used to efficiently transduce both replicating and quiescent cells. The regular lentiviruses are well-known for possessing the ability to stably integrate into their target cell genomes as proviruses. Integrase-deficient lentivirus (IDLV), also known as non-integrating lentivirus (NILV), is a novel technology derived from the regular integrating lentivirus. The major difference between regular lentiviruses and IDLVs is that the former can integrate into cell chromosomes while the latter can not. Lentiviral integrase is a critical protein for virus integrating into the target cell genomic DNA.