Invicro - Preclinical Imaging Services
From Capabilities
Our diverse team of experts have experience in instrument engineering, signal processing, and pharmaceutical R&D, collectively resulting in a long history designing and executing imaging and pathology studies. Our scientists have performed hundreds of studies across multiple therapeutic research areas, including oncology, neuroscience, inflammation, cardiovascular, metabolic, and musculoskeletal, and our experience runs the gamut of applications. We understand the physiological and biochemical mechanisms that affect imaging—targets, models, kinetics, and more. This vast hands-on experience allows us to understand drug behavior and translate knowledge to provide effective studies and useful data.
Servcies Overview
We define imaging as assays that enable visualization of subcellular distribution and processes all the way to translational and diagnostic clinical imaging biomarkers, including everything in between. With all imaging techniques, we use methods to ensure data is quantifiable and leverage our powerful analytics platform to ensure that results can be used to drive meaningful decisions.
Capabilities
Execution of these studies requires the skills of many scientific disciplines and the structure to enable the complex coordination of all facets of the experiment, including animal models, radiolabeled molecules, multiple timepoints, and multi-modal imaging. Invicro has built a research laboratory network with services that are necessary to support these imaging endpoints, and we continue to advance and add to these services to meet the needs of our sponsors. We often develop protocols for novel compounds, work through the radiochemistry needs together with the sponsor, and assist with animal model development as needed. We can perform studies on a range of different species with a large number of administration routes available. Species include rodent, dog, cat, pig, rabbit, sheep, and non-human primates as well as surgical and oncology models.
Key Supporting Capabilities
- Complete radiopharmaceutical and theranostics services
- Disease model development, including tumor inoculation
- Pharmacology, efficacy, and biomarker study execution
- Drug and imaging agent administration, including during scanning
- Blood collection for whole blood, plasma, or serum PK analysis
- Tissue collection and biomarker development
- Gamma and liquid scintillation counting (biodistribution studies)
- Focal beam radiation / Whole body irradiation
Modalities
Invicro is imaging modality agnostic and can apply techniques across therapeutic areas and species. Studies may be single or multi-modal and may combine multiple isotopes or contrast mechanisms. When designing any study, we combine imaging theory, published methods, and the technical and professional expertise of our staff to ensure the appropriate technique is applied to best answer the biological question.
- in vivo: Tissue/Cell-Based
- PET: Quantitative Whole-Body Autoradiography
- SPECT: Microautoradiography
- MRI/MRS: Optical 2D and 3D cryotomography
- CT: Cryofluorescence Tomography (CFT)
- Bioluminescence: Routine and Specialized Histology
- Fluorescence: Immunohistochemistry (IHC)
- Ultrasound: Blood and urine analysis
- Optoacoustic Imaging: Flow Cytometry (FACS)
- Radioligand binding assays (cells and tissues)
Therapeutic Areas
We specialize in the application of imaging in drug research and have experience working in multiple therapeutic areas. Our mission is to be a scientific partner to our sponsoring companies who benefit from our services for the rapid collection of data and advancement of their programs.
Drug Phases
Invicro’s discovery research team can provide guidance on all stages of the early drug development process from the choice of labeling technique, most appropriate imaging modality, choice of animal model, finalized study design, and preferred analysis endpoints to answer biological questions and produce meaningful results. Invicro has multiple sites globally with preclinical imaging facilities in Boston, Michigan, San Diego, New Haven, and London, UK and the site of choice will be dependent on sponsor needs.
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