Drug Molecule Services
38 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in cellular function. Receptors are categorized based on their cellular location into cell surface receptors and intracellular receptors. Each receptor typically has two active sites: one that recognizes and ...
Manufactured by:CD Formulation based in, NEW YORK (USA)
Liposomes are a novel drug delivery system; they are bimolecular vesicle structures that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and serve as carriers for a wide range of drug molecules, such as chemotherapeutic agents, anti-microbial and viral drugs, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein-based macromolecular drugs, typically organic compounds with molecular weights exceeding 1000, depend on cellular biosynthesis and are also known as biologics. Compared to traditional small molecule drugs, protein drugs are characterized by their high potency, strong specificity, low toxicity, clear biological function, ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
In chemical concepts, dominant skeleton refers to the core structure of small molecules. In computational chemistry and medicinal chemistry, the skeleton also has the same meaning. The discovery of active compounds with novel skelecton is a great challenge for modern medicinal chemistry. It can not only improve the efficacy and drug-like properties of ...
by:Acellera based inStanmore, UNITED KINGDOM
This protocol simulates the target of interest (GPCR, kinase, ion channel, etc.) in a solution of water and a co-solvent, like benzene or any other fragment-like molecule. During the simulation, the co-solvent molecules interact with the surface of the protein, revealing binding hotspots. These hotspots have been proven to correlate very well with actual pockets. ...
by:Patheon Inc. based inDurham, NORTH CAROLINA (USA)
Establishing the best synthetic route for your molecule is the basis for a reliable supply throughout the product’s life cycle. During route scouting, the following considerations are important when selecting the optimal pathway: Safety, Efficiency, purity and costs, Ease of optimization and scale up, IP review, Security of supply of raw materials, Impact on waste and the ...
Manufactured by:Alfa Chemistry based inNY, NEW YORK (USA)
The Alfa Chemistry platform integrates predictive methods with various computational techniques to accelerate drug discovery. Our iterative process is designed to accelerate evaluation and optimization of chemical matter in silico ahead of synthesis and assay. The most promising compounds emerging from each round of experimental project chemistry are then further optimized through additional ...
Manufactured by:CD Formulation based in, NEW YORK (USA)
Microsphere Development: Among the many existing extended release formulations, microspheres have unique advantages such as gradual release of the drug by degradation of the microspheres after administration, avoidance of blood concentration peaks and valleys, reduction of the dose during the therapeutic cycle, and improvement of the bioavailability of the drug ...
by:Lightcast Discovery Ltd. based inCambridge, UNITED KINGDOM
Finding rare events: The Lightcast platform is designed to have a high throughput and will be ideally suited to finding one in 10,000 or one in 100,000 ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
mall molecule drugs are chemically synthesized active organic compounds with a low molecular weight usually less than 900 daltons which can be made into tablets or capsules that are easily absorbed. As traditional form of medicine, small molecule drugs have always been an important part of drug research and have ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
The construction of an antibody-drug conjugate (ADC) is the covalent coupling of a monoclonal antibody and a toxic payload drug via a linker molecule. The ultimate goal for an ADC development project is to deploy the resulted ADC into in vivo systems, both in model animals and eventually human patients, to cure cancer and other diseases utilizing ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Hit optimization is a critical step in drug discovery to funnel into lead optimization. Select the most promising hits and leverage H2L, and automated chemical synthesis workflows for faster experimental screening cycles, decreased duration and hands on time, reducing the overall drug discovery timeline leading to promising preclinical candidates. Rapid ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
The construction of an antibody-drug conjugate (ADC) is the covalent coupling of a monoclonal antibody and a toxic payload drug via a linker molecule. The ultimate goal for an ADC development project is to deploy the resulted ADC into in vivo systems, both in model animals and eventually human patients, to cure cancer and other diseases utilizing ...
Manufactured by:Ozgene Pty Ltd. based inBentley DC, AUSTRALIA
Knock-in mice have an insertion in a specific locus in order to produce genetically modified mice for customised research purposes. Reporter genes, human genes, related genes from the same organism, or point mutations can be introduced into the protein-coding region of a gene to produce knock-in mice. The difference between the knock-in and knockout approach is that knock-in mouse models are ...
by:Patheon Inc. based inDurham, NORTH CAROLINA (USA)
Comprehensive upstream process development capabilities, including cell line development, and a commitment to innovation, quality and service, make us the ideal partner for the process development of your mammalian cell culture projects. Our expertise spans multiple commercial cell lines, including CHO (Chinese Hamster Ovary), as well as cGMP cell ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Strateos offers a wide range of the shelf assays and supports custom development of biochemical, biophysical and cellular assays using both industry-standard and innovative technologies to support drug discovery projects from hit identification to lead optimization. We also have broad experience in a variety of target classes ranging from GPCRs, kinases, ion channels, nuclear receptors, proteases ...
by:Solvias AG based inKaiseraugst, SWITZERLAND
We provide rapid and comprehensive support for your early-phase drug development process, enabling you to establish 'critical mass' – in terms of personnel and know-how – in the chemical and analytical development of complex small-molecule ...
Manufactured by:HemoShear Therapeutics, Inc. based inCharlottesville, VIRGINIA (USA)
Using our powerful REVEAL-TxTM drug discovery platform, our scientists are identifying and validating promising approaches to develop novel treatments aiming to extend and improve the quality of life of patients with rare diseases. In our most advanced program, the company is conducting a phase 2 clinical trial of HST5040, an oral small molecule investigational ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Miniaturization is key to facilitating higher throughput, increasing reliability and accuracy and reducing costs for screening large compound libraries. We have a solid track record in miniaturizing challenging assays to 384- and 1536-well formats for medium to Ultra-High-Throughput Screening (uHTS). Strateos’ smart labs collectively span over 14K sqft and are composed of automated ...
by:Strateos Inc. based inMenlo Park, CALIFORNIA (USA)
Hit discovery or hit identification in drug development is driven by the need to identify small molecules with desirable activity in a compound screen against a target. Our state-of-the-art fully automated robotic platform is set-up to accelerate your drug discovery process starting with robust, targeted hit identification services. ...